Recombinant Rat CNTF

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Pricing & Details

Product. No.C329
Alternate Names
Ciliary Neurotrophic Factor, HCNTF
Expression Host
E. coli
Species
Rat
Prod No.
Size
Price
Avail.
Qty
Add to cart
C329-10 µg
10 µg
$179.00
In stock
Max:
Min: 1
Step: 1
C329-50 µg
50 µg
$539.00
In stock
Max:
Min: 1
Step: 1

Background

Ciliary neurotrophic factor (CNTF) is a cytokine1 that supports survival and/or differentiation of a variety of neuronal cell types including sensory, sympathetic, and motoneurons.2 With these abilities, CNTF has implications for Parkinson's disease and cell-replacement therapies for other disorders.3 CNTF mimics the biological actions of leptin while overcoming "leptin resistance" and appears to reduce inflammatory signaling cascades associated with lipid accumulation in liver and skeletal muscle. The advantages and disadvantages of CNTF has shown promise as a therapeutic strategy to alleviate obesity-associated diseases.4

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
afaeqtplt lhrrdlcsrs iwlarkirsd ltalmesyvk hqglnkninl dsvdgvpvas tdrwsemtea erlqenlqay rtfqgmltkl ledqrvhftp tegdfhqaih tlmlqvsafa yqleelmvll eqkipenead gmpatvgdgg lfekklwglk vlqelsqwtv rsihdlrvis shqmgisale shygakdkqm
N-terminal Sequence Analysis
Ala2
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Rat CNTF is Mr 22.8 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Boschero, AC. et al. (2009) Cytokine46(1):65-71.
2. Thoenen, H. et al. (1994) J Neurobiol. 25: 1436
3. Hagg, T. et al. (2008) J Neurosci. 28: 2231
4. Febbraio, MA. et al. (2008) J Mol Med. 86: 353
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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