Recombinant Rat MCP-1

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Pricing & Details

Product. No.M164
Alternate Names
CCL2, GDCF-2, GDCF-2 HC11, HC11, HSMCR30, MCAF, MGC9434, SCYA2, SMC-CF, JE
Expression Host
E. coli
Species
Rat
Prod No.
Size
Price
Avail.
Qty
Add to cart
M164-10 µg
10 µg
$224.00
In stock
Max:
Min: 1
Step: 1
M164-100 µg
100 µg
$512.00
In stock
Max:
Min: 1
Step: 1
M164-500 µg
500 µg
$1,949.00
In stock
Max:
Min: 1
Step: 1
M164-1 mg
1 mg
$3,214.00
In stock
Max:
Min: 1
Step: 1

Background

Monocyte chemotactic protein-1 (MCP-1) is an essential chemokine produced predominantly by macrophages and endothelial cells and is a potent chemotactic factor for monocytes.1,2,3 It can induce the proliferation and activation of killer cells known as CHAK (CC-Chemokine-activated killer). MCP-1 is also a potent activator of human basophils, induces degranulation and the release of histamines. MCP-1 is involved in the pathogenesis of atherosclerosis and myocardial infarction.4

Protein Details

Purity
>90% by SDS Page and analyzed by silver stain.
Endotoxin Level
<1.0 EU/µg as determined by the LAL method
Biological Activity
Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
QPDAVNAPLT CCYSFTGKMI PMSRLENYKR ITSSRCPKEA VVFVTKLKRE ICADPNKEWV QKYIRKLDQN QVRSETTVFY KIASTLRTSA PLNVNLTHKS EANASTLFST TTSSTSVEVT SMTEN
State of Matter
Lyophilized
Predicted Molecular Mass
The molecular weight of Recombinant Rat MCP-1 is Mr 14.1 kDa.
Formulation
The sterile filtered solution was lyophilized with no additives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Yoshimura, T. et al. (1989) J. Exp. Med. 169: 1449
2. Oppenheim, JJ. et al. (1989) J. Exp. Med. 169: 1485
3. Rollins, BJ. et al. (1997) Blood 90: 909
4. Benjamin, EJ. et al. (2005) Ciculation 112: 1113
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.