cytokine storm

The “Cytokine Storm” and Inflammatory Response to SARS-CoV-2

SARS-CoV-2 infection in patients has shown increased secretion of IL-1β, IFN-γ, IP-10/CXCL10, MCP-1/CCL2, IL-4, and IL-10. In addition, the infection has shown elevated levels of inflammatory cytokines such as IL-2, IL-6, IL-7, IL-10, G-CSF, IP-10/CXCL10, MCP-1/CCL2, MIP-1A, and TNF-α generating possible “cytokine storm”1,2. The treatment of cytokine storm has become increasingly important in helping coronavirus patients. Studies have shown that the IL-6R (Interleukin-6 Receptor) plays an important role in alleviating Cytokine Release Syndrome (CRS)2. While causes for inflammatory responses remain widely unknown, Leinco can assist researchers in providing many of these cytokines.

SARS-CoV-2 Increased Secretion & Inflammation of CytokinesSARS-CoV-2 Cytokine Response

Cytokines

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Antibodies to Cytokines

Additional conjugates available for each. 

Product
Clone
Applications
Prod No.
Package Size
88915
N
WB
I-683
100 µg
25 µg
500 µg
ICC
N
WB
I-233
100 µg
25 µg
ICC
N
WB
I-243
100 µg
25 µg
N
WB
I-721
100 µg
25 µg
69604
WB
I-675
25 µg
500 µg
38139
ELISA Indirect
WB
I-672
25 µg
500 µg
53325
ELISA Cap
I-674
100 µg
25 µg
500 µg
ICC
N
WB
I-170
100 µg
25 µg
ELISA Cap
ICC
IHC FFPE
N
WB
M1233
100 µg
25 µg
1 7 8

ELISA Development Kits

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  1. Y. Fu, et al. 2020, Virologica Sinica, 35:266–271
  2. C. Zhang, et al. 2020, International Journal of Antimicrobial Agents, 105954
  3. Image: G. Schett, et al. 2020, Nat Rev Immunol20, 271–272.