The “Cytokine Storm” and Inflammatory Response to SARS-CoV-2
SARS-CoV-2 infection in patients has shown increased secretion of IL-1β, IFN-γ, IP-10/CXCL10, MCP-1/CCL2, IL-4, and IL-10. In addition, the infection has shown elevated levels of inflammatory cytokines such as IL-2, IL-6, IL-7, IL-10, G-CSF, IP-10/CXCL10, MCP-1/CCL2, MIP-1A, and TNF-α generating possible “cytokine storm”1,2. The treatment of cytokine storm has become increasingly important in helping coronavirus patients. Studies have shown that the IL-6R (Interleukin-6 Receptor) plays an important role in alleviating Cytokine Release Syndrome (CRS)2. While causes for inflammatory responses remain widely unknown, Leinco can assist researchers in providing many of these cytokines.
SARS-CoV-2 Increased Secretion & Inflammation of Cytokines
Cytokines
Antibodies to Cytokines
Additional conjugates available for each.
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Product | Clone | Applications | Prod No. | Package Size |
|---|---|---|---|---|
ELISA Cap ⋅ N ⋅ WB | I-166 | 100 µg ⋅ 25 µg | ||
ELISA Indirect ⋅ ICC ⋅ IHC FFPE ⋅ N ⋅ WB | M177 | 100 µg ⋅ 25 µg | ||
39624 | WB | C1418 | 100 µg ⋅ 25 µg ⋅ 500 µg | |
TN3-19.12 | in vivo ⋅ IP ⋅ N ⋅ WB | T258 | 1.0 mg ⋅ 100 mg ⋅ 25 mg ⋅ 5.0 mg ⋅ 50 mg | |
TN3-19.12 | in vivo ⋅ IP ⋅ N ⋅ WB | T703 | 1.0 mg ⋅ 100 mg ⋅ 25 mg ⋅ 5.0 mg ⋅ 50 mg | |
148801 | N | I-696 | 25 µg ⋅ 500 µg | |
99613 | WB | I-689 | 25 µg ⋅ 500 µg | |
ELISA Indirect ⋅ N ⋅ WB | G681 | 100 µg ⋅ 25 µg | ||
83329 | ELISA Cap ⋅ N | G672 | 25 µg ⋅ 500 µg | |
88915 | N ⋅ WB | I-683 | 100 µg ⋅ 25 µg ⋅ 500 µg |
ELISA Development Kits
- Y. Fu, et al. 2020, Virologica Sinica, 35:266–271
- C. Zhang, et al. 2020, International Journal of Antimicrobial Agents, 105954
- Image: G. Schett, et al. 2020, Nat Rev Immunol20, 271–272.
