cytokine storm

The “Cytokine Storm” and Inflammatory Response to SARS-CoV-2

SARS-CoV-2 infection in patients has shown increased secretion of IL-1β, IFN-γ, IP-10/CXCL10, MCP-1/CCL2, IL-4, and IL-10. In addition, the infection has shown elevated levels of inflammatory cytokines such as IL-2, IL-6, IL-7, IL-10, G-CSF, IP-10/CXCL10, MCP-1/CCL2, MIP-1A, and TNF-α generating possible “cytokine storm”1,2. The treatment of cytokine storm has become increasingly important in helping coronavirus patients. Studies have shown that the IL-6R (Interleukin-6 Receptor) plays an important role in alleviating Cytokine Release Syndrome (CRS)2. While causes for inflammatory responses remain widely unknown, Leinco can assist researchers in providing many of these cytokines.

SARS-CoV-2 Increased Secretion & Inflammation of CytokinesSARS-CoV-2 Cytokine Response

Cytokines

Product
Clone
Applications
Prod No.
Package Size
I-202
10 µg
50 µg
G123
25 µg
5 µg
G124
10 µg
50 µg
500 µg
I-179
100 µg
I-193
10 µg
25 µg
5 µg
I-214
25 µg
5 µg
I-196
1.0 mg
10 µg
100 µg
500 µg
I-198
1 mg
100 µg
25 µg
500 µg
I-183
10 µg
25 µg
5 µg
I-184
10 µg
50 µg
500 µg
1 2 6

Antibodies to Cytokines

Additional conjugates available for each. 

Product
Clone
Applications
Prod No.
Package Size
33036
CyTOF®
ELISA Cap
FC
N
C1389
100 µg
25 µg
500 µg
CyTOF®
ELISA Indirect
FC
ICC
IHC
N
I-160
100 µg
25 µg
3316
ELISA Cap
N
G664
100 µg
25 µg
500 µg
N
WB
G114
100 µg
25 µg
6804
CyTOF®
ELISA Cap
FC
G675
100 µg
25 µg
500 µg
3209
ICC
N
WB
G665
100 µg
25 µg
500 µg
ICC
N
WB
I-141
100 µg
25 µg
N
WB
I-851
100 µg
25 µg
24910
ICC
N
WB
I-351
100 µg
25 µg
500 µg
ICC
N
WB
I-329
100 µg
25 µg
1 2 8

ELISA Development Kits

Product
Clone
Applications
Prod No.
Package Size
ELISA
I-423
5 plates
15 plates
ELISA
G658
5 plates
15 plates
ELISA
G149
5 plates
15 plates
ELISA
I-296
5 plates
15 plates
ELISA
I-293
15 plates
ELISA
I-887
5 plates
15 plates
ELISA
I-295
15 plates
ELISA
I-287
5 plates
15 plates
ELISA
I-389
5 plates
15 plates
ELISA
M1109
5 plates
15 plates
1 2 3
  1. Y. Fu, et al. 2020, Virologica Sinica, 35:266–271
  2. C. Zhang, et al. 2020, International Journal of Antimicrobial Agents, 105954
  3. Image: G. Schett, et al. 2020, Nat Rev Immunol20, 271–272.