Recombinant Human CXCL10

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Pricing & Details

Product. No.I-202
Alternate Names
Chemokine (C-X-C Motif) Ligand 10, C7, IFI10, INP10, IP-10, SCYB10, Crg-2, GIP-10, Mob-1
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-202-10 µg
10 µg
$129.00
In stock
Max:
Min: 1
Step: 1
I-202-50 µg
50 µg
$379.00
In stock
Max:
Min: 1
Step: 1

Data

Background

CXCL10, also known as IP-10 and CRG-2, is a small cytokine belonging to the CXC chemokine family. Binding of this protein to the cell surface chemokine receptor CXCR3, results in pleiotropic effects, including stimulation of monocytes, natural killer and T cell migration and modulation of adhesion molecule expression. CXCL10 is secreted by several cell types in response to IFN-γ including monocytes, endothelial cells and fibroblasts (1). CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity and inhibition of bone marrow colony formation and angiogenesis (2-3). Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. CXCL10 plays a role in the regulation of tubular cell proliferation following renal ischemia-reperfusion injury (4). CXCL10 shows anti-microbial and anti-bacterial activity (5-6).

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR3. The ED50 for this effect is 0.03‑0.18 µg/mL.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
mvplsrtvrc tcisisnqpv nprsleklei ipasqfcprv eiiatmkkkg ekrclnpesk aiknllkavs kerskrsp
N-terminal Sequence Analysis
Met
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human CXCL10 is Mr 8.7 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Luster, AD. et al.(1985) Nature 315: 672
2. Dufour, JH. et al.(2002) J. Immunol. 168
3. Angiolillo, AL. et al.(1995) J. Exp. Med. 182: 155
4. Kaneko, S. et al.(2008) Nephron Exp. Nephrol. 109:(1):c29-38
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.