Recombinant Human CXCL1

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Pricing & Details

Product. No.G125
Alternate Names
GRO1, GROa, MGSA, MGSA Alpha, NAP-3, SCYB1, FSP
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
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G125-10 µg
10 µg
$219.00
In stock
Max:
Min: 1
Step: 1
G125-50 µg
50 µg
$639.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Background

Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine with mitogenic properties belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α).1 CXCL1 is expressed by macrophages, neutrophils and epithelial cells.2 CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing.3,4

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human GRO/MGSA was determined by its ability to induce myeloperoxidase release from cytochalasin treated neutrophils (Schröder, J. et al., 1987, J. Immunol. 139:3474), or chemotaxis of mouse BaF/3 cells transfected with hCXCR2. The expected ED50 for these effects are typically 0.15 - 0.3 μg/ml or 1 - 4 ng/ml, respectively.
Expression Host
E. coli
Protein Accession No.
P09341
Amino Acid Sequence
asvate lrcqclqtlq gihpkniqsv nvkspgphca qteviatlkn grkaclnpas pivkkiiekm lnsdksn
N-terminal Sequence Analysis
Ala35
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human CXCL1 is Mr 7.9 kDa.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Sager, R. et al. (1990) Proc. Natl. Acad. Sci. U.S.A. 87: 7732
2. Grotendorst, GR. et al. (1990) Mol. Cell. Biol. 10: 5596
3. Miller, RH. et al. (2002) Cell 110: 373
4. Richmond, A. et al. (2000) J. Invest. Dermatol. 115: 234
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.