Recombinant Mouse KC/CXCL1

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Pricing & Details

Product. No.K114
Alternate Names
Chemokine (C-X-C Motif) Ligand 1, KC, GRO1, GROa, MGSA, MGSA Alpha, NAP-3, SCYB1, CINC-1
Expression Host
E. coli
Species
Mouse
Prod No.
Size
Price
Avail.
Qty
Add to cart
K114-10 µg
10 µg
$285.00
In stock
Max:
Min: 1
Step: 1
K114-50 µg
50 µg
$459.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Background

CXCL1 is a small cytokine with mitogenic properties belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α).1 CXCL1 is expressed by macrophages, neutrophils and epithelial cells.2 CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing.3,4

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Mouse KC aa 20 - 96 was determined by its ability to induce myeloperoxidase release from cytochalasin B treated neutrophils (Schröder, J.M., et al., 1987, J. Immunol. 139:3474) or chemotaxis of mouse BaF/3 hCXCR2 transfected cells. . The expected ED50 for these effects are typically 0.3 - 0.9 μg/ml or 3 - 15 ng/ml, respectively.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
rlatgapian elrcqclqtm agihlkniqs lkvlpsgphc tqteviatlk ngreacldpe aplvqkivqk mlkgvpk
N-terminal Sequence Analysis
Arg20
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse KC is Mr 8 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Sager, R. et al. (1990) Proc. Natl. Acad. Sci. U.S.A. 87: 7732
2. Grotendorst, GR. et al. (1990) Mol. Cell. Biol. 10: 5596
3. Miller, RH. et al. (2002) Cell 110: 373
4. Richmond, A. et al. (2000) J. Invest. Dermatol. 115: 234
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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