The “Cytokine Storm” and Inflammatory Response to SARS-CoV-2
SARS-CoV-2 infection in patients has shown increased secretion of IL-1β, IFN-γ, IP-10/CXCL10, MCP-1/CCL2, IL-4, and IL-10. In addition, the infection has shown elevated levels of inflammatory cytokines such as IL-2, IL-6, IL-7, IL-10, G-CSF, IP-10/CXCL10, MCP-1/CCL2, MIP-1A, and TNF-α generating possible “cytokine storm”1,2. The treatment of cytokine storm has become increasingly important in helping coronavirus patients. Studies have shown that the IL-6R (Interleukin-6 Receptor) plays an important role in alleviating Cytokine Release Syndrome (CRS)2. While causes for inflammatory responses remain widely unknown, Leinco can assist researchers in providing many of these cytokines.
SARS-CoV-2 Increased Secretion & Inflammation of Cytokines
Cytokines
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Product | Clone | Applications | Prod No. | Package Size |
|---|---|---|---|---|
I-217 | 100 µg | |||
ELISA Cap ⋅ FC | I-835 | 10 µg | ||
I-211 | 100 µg ⋅ 25 µg ⋅ 5 µg | |||
I-1180 | 1.0 mg ⋅ 10 µg ⋅ 100 µg ⋅ 500 µg | |||
I-219 | 10 µg ⋅ 50 µg ⋅ 500 µg | |||
ELISA Cap ⋅ FC | I-843 | 10 µg | ||
I-533 | 25 µg | |||
ELISA ⋅ FC ⋅ WB | I-1191 | 10 µg ⋅ 50 µg ⋅ 500 µg | ||
I-205 | 10 µg ⋅ 25 µg ⋅ 5 µg | |||
ELISA Cap ⋅ FC | I-837 | 20 µg |
Antibodies to Cytokines
Additional conjugates available for each.
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Product | Clone | Applications | Prod No. | Package Size |
|---|---|---|---|---|
IHC ⋅ N ⋅ WB | M142 | 100 µg ⋅ 25 µg | ||
14215 | ELISA ⋅ N | C1447 | 100 µg ⋅ 25 µg ⋅ 500 µg | |
93321 | ELISA Indirect ⋅ IHC FFPE ⋅ N ⋅ WB | C1390 | 100 µg ⋅ 25 µg ⋅ 500 µg | |
123616 | N | C1427 | 100 µg ⋅ 25 µg ⋅ 500 µg | |
134013 | ELISA Cap ⋅ N ⋅ WB | C1423 | 100 µg ⋅ 25 µg ⋅ 500 µg | |
IHC FF ⋅ N ⋅ WB | I-236 | 100 µg ⋅ 25 µg | ||
67604 | ELISA Cap ⋅ N ⋅ WB | G669 | 100 µg ⋅ 25 µg ⋅ 500 µg | |
ELISA Indirect ⋅ N ⋅ WB | G134 | 100 µg ⋅ 25 µg | ||
N ⋅ WB | G119 | 100 µg ⋅ 25 µg | ||
MP1-22E9 | in vivo ⋅ N ⋅ WB | G670 | 1.0 mg ⋅ 100 mg ⋅ 25 mg ⋅ 5.0 mg ⋅ 50 mg |
ELISA Development Kits
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Product | Clone | Applications | Prod No. | Package Size |
|---|---|---|---|---|
ELISA | H255 | 25 µg ⋅ 250 µg ⋅ 5 µg |
- Y. Fu, et al. 2020, Virologica Sinica, 35:266–271
- C. Zhang, et al. 2020, International Journal of Antimicrobial Agents, 105954
- Image: G. Schett, et al. 2020, Nat Rev Immunol20, 271–272.
