The “Cytokine Storm” and Inflammatory Response to SARS-CoV-2

SARS-CoV-2 infection in patients has shown increased secretion of IL-1β, IFN-γ, IP-10/CXCL10, MCP-1/CCL2, IL-4, and IL-10. In addition, the infection has shown elevated levels of inflammatory cytokines such as IL-2, IL-6, IL-7, IL-10, G-CSF, IP-10/CXCL10, MCP-1/CCL2, MIP-1A, and TNF-α generating possible “cytokine storm”1,2. The treatment of cytokine storm has become increasingly important in helping coronavirus patients. Studies have shown that the IL-6R (Interleukin-6 Receptor) plays an important role in alleviating Cytokine Release Syndrome (CRS)2. While causes for inflammatory responses remain widely unknown, Leinco can assist researchers in providing many of these cytokines.

SARS-CoV-2 Increased Secretion & Inflammation of CytokinesSARS-CoV-2 Cytokine Response

Cytokines

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- -
Product
Clone
Applications
Prod No.
Package Size
I-452
1 mg
10 µg
100 µg
500 µg
I-186
10 µg
20 µg
50 µg
I-188
100 µg
I-189
10 µg
25 µg
5 µg
M156
10 µg
50 µg
M161
10 µg
50 µg
L145
25 µg
T153
100 µg
2 mg
20 µg
5 µg
G129
25 µg
5 µg
G128
10 µg
20 µg
5 µg
1236

Antibodies to Cytokines

Additional conjugates available for each. 

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- -
Product
Clone
Applications
Prod No.
Package Size
34593
N
WB
I-639
100 µg
25 µg
500 µg
IHC FFPE
N
WB
I-157
100 µg
25 µg
41809
ELISA Cap
IHC
IP
N
I-655
100 µg
25 µg
500 µg
CyTOF®
FC
ICC
IHC FF
IP
N
WB
I-159
100 µg
25 µg
MP4-25D2
CyTOF®
IHC
in vivo
N
WB
I-1163
1 mg
100 mg
25 mg
5 mg
50 mg
6708
ELISA Cap
IHC
N
WB
I-633
100 µg
25 µg
500 µg
7417
ELISA Cap
N
WB
I-175
100 µg
25 µg
500 µg
N
WB
I-151
100 µg
25 µg
23002
IHC FFPE
M1271
100 µg
25 µg
500 µg
24822
N
WB
M152
100 µg
25 µg
500 µg
1238

ELISA Development Kits

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- -
Product
Clone
Applications
Prod No.
Package Size
ELISA
M1118
5 plates
15 plates
ELISA
G701
5 plates
15 plates
ELISA
I-297
5 plates
15 plates
ELISA
I-403
5 plates
15 plates
ELISA
I-284
5 plates
15 plates
ELISA
I-288
5 plates
15 plates
ELISA
I-893
5 plates
15 plates
ELISA
M1324
5 plates
15 plates
ELISA
J104
5 plates
15 plates
ELISA
M1119
5 plates
15 plates
123
  1. Y. Fu, et al. 2020, Virologica Sinica, 35:266–271
  2. C. Zhang, et al. 2020, International Journal of Antimicrobial Agents, 105954
  3. Image: G. Schett, et al. 2020, Nat Rev Immunol20, 271–272.