Anti-Human IL-17 (Clone 41809)

Purified Recombinant Human IL-17 (Accession # Q16552)

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

Next Day Ambient

Neutralization: This antibody is useful for neutralization of Human IL-17 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human IL-17 (at 25 ng/ml) is 1-3 µg/ml.
Immunohistochemistry: Suitable for use at concentration of 5-25 µg/mL.
Immunoprecipitation: Suitable for use at concentration of 3 µg/100 µg cell lysate.

Mouse Anti-Human Interleukin 17 (IL-17) (Clone 41809) recognizes an epitope on Human IL-17. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Interleukin 17 (IL-17) is a T cell cytokine that induces monocyte migration and inflammation.¹ IL-17-producing cell could serve as a potential prognostic marker and a novel therapeutic target for hepatocellular carcinoma (HCC).² IL-17 may be important in recruiting monocytes into the joints of patients with RA, supporting IL-17 as a therapeutic target in RA.¹

1. Pope, RM. et al. (2009) J Immunol. 182: 3884
2. Zheng, L. et al. (2009) J Hepatol. 50(5):980-989.