Recombinant Mouse IL-17

Recombinant Mouse IL-17

Product No.: I-533

[product_table name="All Top" skus="I-533"]

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Alternate Names
Interleukin-17, CTLA8, IL17A
Product Type
Recombinant Protein
Expression Host
E. coli Cells
Species
Mouse

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Select Product Size
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Background

Interleukin 17 (IL-17) is a T cell cytokine that induces monocyte migration and inflammation.1 IL-17-producing cell could serve as a potential prognostic marker and a novel therapeutic target for hepatocellular carcinoma (HCC).2 IL-17 may be important in recruiting monocytes into the joints of patients with RA, supporting IL-17 as a therapeutic target in RA.1

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Mouse IL-17 was determined by its ability to induce IL-6 production by NIH/3T3 cells. The expected ED<sub>50</sub> for this effect is typically 0.25 - 1.25 ng/ml.
Protein Accession No.
Amino Acid Sequence
tvkaaaiip qssacpntea kdflqnvkvn lkvfnslgak vssrrpsdyl nrstspwtlh rnedpdryps viweaqcrhq rcvnaegkld hhmnsvliqq eilvlkrepe scpftfrvek mlvgvgctcv asivrqaa
N-terminal Sequence Analysis
Thr22
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse IL-17A is Mr 15.5 kDa.
Predicted Molecular Mass
15.5
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Pope, RM. et al. (2009) J Immunol. 182: 3884
2. Zheng, L. et al. (2009) J Hepatol. 50(5):980-989.

Certificate of Analysis

IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
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Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.