Anti-Gonadotropin Releasing Hormone (GnRH) Library Pack [4 Clones]

Gonadotropin Releasing Hormone (GnRH / LHRH)

Overview for Assay Development & Diagnostics
Gonadotropin Releasing Hormone (GnRH), historically referred to as Luteinizing Hormone-Releasing Hormone (LHRH) or Progonadoliberin I, is a highly conserved decapeptide (pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) essential for regulating the reproductive axis. Because GnRH is secreted in pulsatile bursts into the hypophyseal portal bloodstream, accurate and highly sensitive detection is critical for both basic research and clinical assay development.

For assay developers, GnRH represents a challenging but vital biomarker. Its small size requires high-affinity, rigorously validated monoclonal antibodies to ensure robust performance in sandwich ELISAs, Radioimmunoassays (RIA), and rapid diagnostic platforms. This antibody library pack provides four distinct clones, offering developers the critical flexibility needed to screen for optimal capture/detection matched pairs, evaluate cross-reactivity, and fine-tune assay kinetics.
Biological Significance and Research Applications
Synthesized primarily in the preoptic area of the hypothalamus, GnRH serves as the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Upon release, it binds to the GnRH receptor (GnRHR) on anterior pituitary gonadotropes, stimulating the synthesis and secretion of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH).

In addition to its classical endocrine role, GnRH signaling is a major focal point in several advanced research areas:

Neuroendocrinology & Reproductive Biology: Investigating the mechanisms of puberty, infertility (e.g., hypogonadotropic hypogonadism), and the pulsatile dynamics of hormone secretion.

Oncology & Therapeutics: GnRH and its receptors are often expressed in hormone-dependent cancers, including prostate, breast, and ovarian cancers. GnRH analogs (agonists and antagonists) are standard therapeutic agents, making GnRH tracking essential for therapeutic monitoring and drug discovery.

Spatial Biology & Neuroscience: Mapping GnRH neuron networks and tracking neurogenesis using Immunohistochemistry (IHC) and Immunofluorescence (IF).

Purified human gonadotropin releasing hormone

These antibodies recognize human GnRH.

Leinco's manufactured in Satin Louis, Missouri USA and Antibodies are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Why Use a Library Pack?
Due to the brief half-life of GnRH in circulation and its small molecular weight, selecting the correct antibody is paramount to assay success. This library pack empowers researchers and diagnostic manufacturers to empirically determine the best-performing clone or combination of clones for their specific assay format, matrix conditions, and required sensitivity limits.

Anti-Gonadotropin Releasing Hormone Mouse Monoclonal Antibody Library Pack - Includes 100 ug of each of the following antibodies:

19301 - Anti-Gonadotropin Releasing Hormone Mouse Monoclonal Antibody - Clone LHRH13-327.8 - Isotype IgG1

19302 - Anti-Gonadotropin Releasing Hormone Mouse Monoclonal Antibody - Clone LHRH13-372.14 - Isotype IgG1

19303 - Anti-Gonadotropin Releasing Hormone Mouse Monoclonal Antibody - Clone LHRH13-387.5 - Isotype IgG1

19304 - Anti-Gonadotropin Releasing Hormone Mouse Monoclonal Antibody - Clone LHRH13-426.12 - Isotype IgG1

These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.