Anti-Helicobacter pylori Antibody (18932)
Anti-Helicobacter pylori Antibody (18932)
Product No.: 18932
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Clone HP1811 Target Helicobacter pylori Formats AvailableView All Product Type Monoclonal Isotype Mouse IgG Applications ELISA,WB |
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Antibody DetailsProduct DetailsReactive Species H. Pylori Cag A Protein Host Species Mouse Immunogen Recombinant fragments of H. pylori CagA protein Product Concentration Lot Specific Formulation PBS, pH 7.4, 0.09% sodium azide. State of Matter Liquid Product Preparation Purified by Protein A affinity chromatography Storage and Handling Store product at 4°C. Regulatory Status Research Use Only Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco ELISA, Immunoblotting
End users should determine optimal antibody concentrations relative to their preparations of H. pylori. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity This antibody recognizes an epitope between Asp562 and Gln795 of H. pylori Cag A protein. Background Helicobacter pylori, first associated with peptic ulcer disease, is now also associated with gastric cancer. Investigations by Backert and Blaser of H.pylori genes and antigens identified the 128kDa CagA protein (product of the cagA gene) as a protein associated with an increased risk of gastric cancer. During infection, CagA localizes to the host plasma membrane and undergoes tyrosine phosphorylation. Subsequently, the various forms of CagA interact with >25 host signaling factors promoting proinflammatory, proliferative, cell cycle–related, and antiapoptotic gene alterations. Alterations in cellular growth and of epithelial integrity by CagA can trigger precancerous alterations in the stomach, which is one explanation for the high frequency of gastric cancer in patients carrying CagA+H. pylori. NCBI Gene Bank ID Research Area Infectious Disease References & Citations |
Formats Available
