Anti-Henipavirus (Clone: HENV-117)

Pricing & Details

Product No.LT576
Clone
HENV-117
Protein
Henipavirus
Formats AvailableView All
Product Type
Recombinant Monoclonal Antibody
Isotype
Human IgG1
Applications
FC
,
N
Prod No.
Size
Price
Avail.
Qty
Add to cart
LT576-250 µg
250 µg
$390.00
Pre-order
Max:
Min: 1
Step: 1
LT576-1.0 mg
1.0 mg
$1,400.00
Pre-order
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Henipavirus
Virus
Expression Host
HEK-293
Immunogen
HENV-117 was isolated from circulating B cells of an individual exposed to equine HeV vaccine.
Product Concentration
≥ 5.0 mg/ml
Endotoxin Level
≤ 1.0 EU/mg as determined by the LAL method
Purity
≥95% monomer by analytical SEC
Formulation
This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Storage and Handling
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≥ -70°C. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Standard Overnight on Blue Ice.
Other Applications Reported In Literature ?
FC
N
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
HENV-117 activity is directed against the receptor-binding domain of receptor binding protein (RBP). HENV-117, has shown to neutralizes HeV, NiVM, or NiVB with exceptional potency according to the literature and HENV-117 maps to the receptor-binding domain of HeV-RBP and displays a receptor-blocking phenotype. Binding decreases substantially in the presence of ephrin-B2, indicating HENV-117 neutralizes by blocking binding of virus to host cells. nsEM mapping shows that HENV-117 mimics ephrin-B2 binding. 5

Antigen Distribution
Henipavirus RBP is an envelope glycoprotein.
Background
Henipavirus spp. are enveloped, single-stranded RNA viruses in the family Paramyxovirus1. Five species have been identified, two of which, Hendra virus (HeV) and Nipah virus (NiV), are highly virulent emerging pathogens with high case-fatality ratios. The other three species, Cedar virus, Ghanaian bat virus, and Mojiang virus are not known to cause human disease. Pteropid bats are the reservoir host. HeV is transmitted by direct contact with infected horses, their fluids, or tissues1. Horses are infected by exposure to pteropid bats. NiV is transmitted by contact with infected pigs or bats and person-to-person. Both HeV and NiV cause severe influenza-like illness that can progress to encephalitis.

Antigen Details

Research Area
Henipavirus
.
Infectious Disease
.
Viral

References & Citations

1. Shoemaker T, Choi MJ. Chapter 4: Travel-Related Infectious Diseases, Henipaviruses. In: Brunette GW, Nemhauser JB, eds. 2020 CDC Yellow Book. CDC; National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Global Migration and Quarantine (DGMQ), Link Text
2. Aguilar HC, Ataman ZA, Aspericueta V, et al. J Biol Chem. 284(3):1628-1635. 2009.
3. Mire CE, Chan YP, Borisevich V, et al. J Infect Dis. 221(Suppl 4):S471-S479. 2020.
4. Zhu Z, Dimitrov AS, Bossart KN, et al. J Virol. 80(2):891-899. 2006.
5. Doyle MP, Kose N, Borisevich V, et al. Cell Rep. Aug 31;36(9):109628. 2021.
Flow Cytometry

Formats Available

Prod No.
Description
LT576
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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