Anti-Human β-Amyloid Precursor Protein (AβNT) (APP)

Pricing & Details

  
Product Type
Polyclonal Antibody
Applications
IHC (Paraffin)
,
WB
Prod No.
Size
Price
Avail.
Qty
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A162-0.1 mg
0.1 mg
$355.00
In stock
  

Antibody Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:A280
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Description

Specificity
Rabbit Anti-Human β-Amyloid Precursor Protein (APP) recognizes an epitope near the N-terminus of AB of Human, Mouse and Rat APP. This polyclonal antibody was purified using affinity chromatography.
Background
Accumulation of the amyloid-β peptide (αβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The b-amyloid protein precursor (APP) is cleaved by β-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide (αβ), which is deposited in the brains of all suffers of Alzheimer's disease.

Antigen Details

Protein Family
β-Amyloid Precursor Protein
NCBI Gene Bank ID

References & Citations

1. Ponte, P. et al. (1988) Nature 331:525 2. Selkoe, D. J. (1994) Annu. Rev. Cell Biol. 10:373
Immunohistochemistry
General Western Blot Protocol
  
Products are for research use only. Not for use in diagnostic or therapeutic procedures.