Anti-Human β-Amyloid Precursor Protein (AβNT) (APP)

Pricing & Details

Product No.A162
Protein
β-Amyloid Precursor Protein
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
A162-0.1 mg
0.1 mg
$365.00
In stock
Max:
Min: 1
Step: 1

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:A280
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human β-Amyloid Precursor Protein (APP) recognizes an epitope near the N-terminus of AB of Human, Mouse and Rat APP. This polyclonal antibody was purified using affinity chromatography.
Background
Accumulation of the amyloid-β peptide (αβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The b-amyloid protein precursor (APP) is cleaved by β-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide (αβ), which is deposited in the brains of all suffers of Alzheimer's disease.

Antigen Details

NCBI Gene Bank ID

References & Citations

1. Ponte, P. et al. (1988) Nature 331:525 2. Selkoe, D. J. (1994) Annu. Rev. Cell Biol. 10:373
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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