Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human β-Amyloid Precursor Protein (APP) recognizes an epitope near the C-terminus of Human, Mouse and Rat β-Amyloid Precursor Protein. This polyclonal antibody was purified using affinity chromatography.
Accumulation of the amyloid-β peptide (αβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The b-amyloid protein precursor (APP) is cleaved by β-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-β peptide (αβ), which is deposited in the brains of all suffers of Alzheimer’s disease.
NCBI Gene Bank ID
References & Citations
1. Ponte, P. et al. (1988) Nature 331:525 2. Selkoe, D. J. (1994) Annu. Rev. Cell Biol. 10:373
Products are for research use only. Not for use in diagnostic or therapeutic procedures.