Anti-Human CD194 (CCR4) (Mogamulizumab) – Biotin

Anti-Human CD194 (CCR4) (Mogamulizumab) – Biotin

Product No.: LT1001

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Product No.LT1001
Clone
KW-0761
Target
CD194
Product Type
Biosimilar Recombinant Human Monoclonal Antibody
Alternate Names
Mogamulizumab, CD194, CCR4
Isotype
Human IgG1κ
Applications
Depletion
,
ELISA
,
FA
,
FC

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Antibody Details

Product Details

Reactive Species
Human
Expression Host
HEK-293 Cells
FC Effector Activity
Active
Immunogen
Humanization of mouse anti-CCR4 mAb7.
Product Concentration
0.5 mg/ml
Formulation
This Biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
Functional grade biosimilar antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Regulatory Status
Research Use Only (RUO). Non-Therapeutic.
Country of Origin
USA
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
FC The suggested concentration for Mogamulizumab biosimilar antibody for staining cells in flow cytometry is ≤ 1.0 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application.
ELISA
Additional Applications Reported In Literature ?
FA
Additional Reported Applications For Relevant Conjugates ?
Depletion
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Mogamulizumab. Clone KW-0761 recognizes human CD194 (CCR4). This product is for research use only.
Background
Clone KW-0761 (Mogamulizumab) is a research-grade, afucosylated, humanized monoclonal antibody generated from mouse anti-CCR4 mAb7 that targets human CCR4.1 CC chemokine receptor type 4 (CCR4) is a protein that belongs to the G protein-coupled receptor family and is a receptor for a variety of CC chemokines including MCP-1, MIP-1, RANTES, TARC, and Macrophage-derived chemokine. Chemokines are involved in the development, homeostasis, and function of the immune system and are known to regulate cell trafficking of various types of leukocytes. In a 2018 Phase I clinical trial, Mogamulizumab was found to decrease the number of HTLV-1–infected cells and the levels of inflammatory markers related to HTLV-1–Associated Myelopathy.3
Antigen Distribution
CCR4 is primarily expressed by Th2 and regulatory T cells in addition to expression on leukemic cells in cutaneous T-cell lymphoma (CTCL).

Antigen Details

PubMed
NCBI Gene Bank ID
Research Area
Cancer
.
Immuno-Oncology
.
Immunology

References & Citations

1. Yamamoto, K. et al. (2010) J Clin Oncol. 28(9):1591-8.
2. Mimura, Y. et al. (2018) Protein Cell 9(1):47-62.
3. Yamano, Y. et al. (2018) N Engl J Med 378 (6), 529-538.
Depletion
Indirect Elisa Protocol
FA
Flow Cytometry

Certificate of Analysis

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.