Anti-Human ICAM-1 – DyLight® 650

Anti-Human ICAM-1 – DyLight® 650

Product No.: C1659

[product_table name="All Top" skus="C1659"]

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Clone
15.2
Target
ICAM-1
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
BB2, CD54, P3.58
Isotype
IgG1
Applications
FC

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Immunogen
Purified Recombinant Human ICAM-1 (>98%)
Product Concentration
0.2 mg/ml
Formulation
This DyLight® 650 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This DyLight® 650 conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Excitation Laser
Red Laser (652 nm)
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone 15.2 recognizes an epitope on human ICAM-1.
Antigen Distribution
CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes.
Background
ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.

Antigen Details

PubMed
NCBI Gene Bank ID
Research Area
Cell Adhesion
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Cell Biology
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Costimulatory Molecules
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Immunology
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Neuroscience
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Neuroscience Cell Markers
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Stem Cell

References & Citations

1. Li, S. et al. (2009) Biochem Biophys Res Commun. 381: 459 2. Wolf, S. et al. (2009) Pharmacol Rep 61: 22 3. Ozcan, U. et al. (2009) Arch Gynecol Obstet.
Flow Cytometry
Products are for research use only. Not for use in diagnostic or therapeutic procedures.