Anti-Human IGFBP-2 (Clone 92320)

Product No.: I-693


Clone 92320 Target IGFBP-2 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Insulin-Like Growth Factor Binding Protein 2, IBP-2,IGF-BP53 Isotype IgG2a Applications WB


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Antibody Details Product Details Reactive Species Human Host Species Mouse Immunogen NS0-Derived Recombinant Human IGFBP-2 (Accession # CAA34373) Endotoxin Level <0.1 EU/µg as determined by the LAL method Formulation This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. Storage and Handling The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months. Country of Origin USA Shipping Next Day Ambient RRIDAB_2830814 Applications and Recommended Usage? Quality Tested by Leinco Western Blotting: To detect Human IGFBP-2 this monoclonal antibody can be used at a concentration of 1-2 µg/ml. This monoclonal antibody should be used in conjunction with compatible second-step reagents such as PN:M114 and a chromogenic substrate such as PN:T343. The detection limit for Human IGFBP-2 is 50 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Mouse Anti-Human Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) (Clone 92320) recognizes an epitope on Human IGFBP-2. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Background Insulin-like growth factor binding protein 2, also known as IGFBP2, is an extracellular unglycosylated polypeptide that specifically binds IGF and modulates its effects.¹ IGFBP-2 has direct effects on breast cancer proliferation via stimulation of critical signaling pathways.² PubMed IGFBP-2 NCBI Gene Bank ID 3485 UniProt.org Information on Uniprot.org References & Citations 1. Luthman, H. et al.(1991) Biochem Biophys Res Commun. 176: 1250 2. Disis, ML. et al.(2008) Cancer Res. 68: 8400 View product citations for antibody I-693 on CiteAb Technical Protocols Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Human

Host Species

Mouse

Immunogen

NS0-Derived Recombinant Human IGFBP-2 (Accession # CAA34373)

Endotoxin Level

<0.1 EU/µg as determined by the LAL method

Formulation

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Storage and Handling

The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

Country of Origin

USA

Shipping

Next Day Ambient

RRIDAB_2830814

Applications and Recommended Usage?
Quality Tested by Leinco

Western Blotting: To detect Human IGFBP-2 this monoclonal antibody can be used at a concentration of 1-2 µg/ml. This monoclonal antibody should be used in conjunction with compatible second-step reagents such as PN:M114 and a chromogenic substrate such as PN:T343. The detection limit for Human IGFBP-2 is 50 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Mouse Anti-Human Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) (Clone 92320) recognizes an epitope on Human IGFBP-2. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background

Insulin-like growth factor binding protein 2, also known as IGFBP2, is an extracellular unglycosylated polypeptide that specifically binds IGF and modulates its effects.¹ IGFBP-2 has direct effects on breast cancer proliferation via stimulation of critical signaling pathways.²

PubMed

IGFBP-2

NCBI Gene Bank ID

3485

UniProt.org

Information on Uniprot.org

References & Citations

1. Luthman, H. et al.(1991) Biochem Biophys Res Commun. 176: 1250
2. Disis, ML. et al.(2008) Cancer Res. 68: 8400

View product citations for antibody I-693 on CiteAb

Certificate of Analysis

Request COA

Prod No.	Description
I-694	Anti-Human IGFBP-2 (Clone 92326)
I-731	Anti-Human IGFBP-2
I-693	Anti-Human IGFBP-2 (Clone 92320)
I-711	Anti-Mouse IGFBP-2 (Clone 150101)
I-588	Recombinant Mouse IGFBP-2
I-801	Anti-Mouse IGFBP-2 – Biotin
I-791	Anti-Human IGFBP-2 – Biotin

Formats Available

Prod No.	Description
I-693	Anti-Human IGFBP-2 (Clone 92320)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

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Anti-Human IGFBP-2 (Clone 92320)