Anti-Human Nerve Growth Factor Receptor (NGFR)

Purified Recombinant Human NGFR (>98%)

This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.

Lyophilized

The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.

Next Day Ambient

Goat Anti-Human Nerve Growth Factor Receptor (NGFR) recognizes Human NGFR. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

Nerve growth factor receptor (NGFR), also known as the low-affinity receptor p75NTR is a transmembrane glycoprotein without intrinsic tyrosine kinase activity, whose expression is not restricted to neural cells. NGFR is reported to act as a tumour suppressor, negatively regulating cell growth and proliferation.¹ It is also involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination.² p75NGFR contributes to delayed neuronal death (DND) after ischemia by an apoptotic mechanism.³

1. Ashworth, A. et al. (2006) Modern Path. 19: 307
2. Carter, BD. et al. (2004) Prog. Brain Res. 146: 25
3. Itano, T. et al. (2001) Acta Med Okayama 55: 19