Anti-Human TRAIL R3 (Clone 90903)

Anti-Human TRAIL R3 (Clone 90903)

Product No.: T449

[product_table name="All Top" skus="T449"]

- -
- -
Clone
90903
Target
TRAIL R3
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
TRID, TNFRSF10C, CD263, DCR1, LIT, MGC149501, MGC149502, TNF-Related Apoptosis-Inducing Ligand Receptor 3
Isotype
IgG1
Applications
N

- -
- -
Product Size
- -
- -

Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Immunogen
NS0-Derived Recombinant Human TRAIL Receptor 3
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Formulation
This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Storage and Handling
The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Country of Origin
USA
Shipping
Next Day Ambient
Additional Applications Reported In Literature ?
Neutralization: This antibody is useful for neutralization of Human TRAIL R3 bioactivity. The antibody dose required to neutralize 50% (ND50) of the biological activity of Human TRAIL R3 (at 20 ng/ml) is 0.02 - 0.08 µg/ml.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse Anti-Human TRAIL Receptor 3 (TRAIL R3) (Clone 90903) recognizes an epitope on Human TRAIL R3. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. The antibody displayed approximately 20% - 40% cross-reactivity with rhTRAIL RI and negligible cross-reactivity with rhTRAIL R2 and rhTRAIL R4.
Background
TNF-related apoptosis-inducing ligand receptor 3 (TRAIL R3) is an antagonist decoy receptor1 that can inhibit TRAIL-induced apoptosis.2 TRAIL R3 is a plasma membrane-bound protein capable of high affinity interaction with the TRAIL ligand.3

Antigen Details

PubMed

References & Citations

1. Fornace Jr, AJ. et al. (1999) Oncogene 18: 4153
2. Büchler, MW. et al. (2001) Anticancer Res. 21: 3153
3. Smith, CA. et al. (1997) J Exp Med. 186: 1165
- -
- -

Formats Available

- -
- -
Prod No.
Description
T449
Products are for research use only. Not for use in diagnostic or therapeutic procedures.