Anti-Human Transient Receptor Potential Channel 6 (CT) (TRPC6)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human Transient Receptor Potential Channel 6 (CT) (TRPC6)

Pricing & Details

Product No.T289
Protein
Transient Receptor Potential Channel 6
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Short Transient Receptor Potential Channel 6, Htrp6
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
T289-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
T289-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Product Concentration
1.0 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Transient Receptor Potential Channel 6 (TRPC6) recognizes an epitope near the C-terminus of Human, Mouse and Rat TRPC6. This polyclonal antibody was purified using affinity chromatography.
Background
The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the “canonical TRP” (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types.1 Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, TRPC6 acts as a non-selective store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.

Antigen Details

References & Citations

1. Contell, C. et al. (2002) Mol. Cell 9:229
2. Dietrich, A. et al. (2005) Pflugers Arch. 451:72
3. Trebak, M. et al. (2003) Cell Calcium 33:451
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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