Anti-Human Transient Receptor Potential Channel 6 (NT) (TRPC6)
Pricing & Details
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human Transient Receptor Potential Channel 6 (TRPC6) recognizes an epitope near the N-terminus of Human and Mouse TRPC6. This polyclonal antibody was purified using affinity chromatography.
The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the “canonical TRP” (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types.. Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, TRPC6 acts as a non-selective store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.
References & Citations
1. Contell, C. et al. (2002) Mol. Cell 9:229
2. Dietrich, A. et al. (2005) Pflugers Arch. 451:72
3. Trebak, M. et al. (2003) Cell Calcium 33:451
Products are for research use only. Not for use in diagnostic or therapeutic procedures.