Anti-Human Vitronectin Antibody (42025)

Anti-Human Vitronectin Antibody (42025)

Product No.: 42025

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Clone
VN58-1
Target
Vitronectin
Formats AvailableView All
Product Type
Monoclonal
Alternate Names
VN, S-protein, Serum-spreading factor, V75 [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B]
Isotype
IgG1
Applications
ELISA
,
IHC
,
WB

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Select Product Size
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Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Immunogen
Human Vitronectin
Formulation
10 mM PBS, 1% BSA, pH 7.4, lyophilized
State of Matter
Lyophilized
Product Preparation
Purified by immunoaffinity chromatography
Storage and Handling
The stock solution (2. 0mg/ml) can be stored in aliquots at - 20°C for 1 year or can be stored at 4°C for 6 months after adding 0.1% sodium azide. Dilutions of stock solution should not be stored.
Country of Origin
USA
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
ELISA: 1:3,000 dilution with solid phase antigen

Western Blot: 5-10 ug/ml under reduced and non-reduced conditions.

Immunohistochemistry: 5-10 ug/ml on paraffin embedded and frozen tissue sections.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse monoclonal antibody that specifically reacts with an epitope in the region of amino acids 1- 130 of human vitronectin. It does not react with bovine vitronectin, and this antibody does not interfere with vitronectin-mediated adhesion.

Antigen Details

Function
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.; Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
NCBI Gene Bank ID
UniProt.org
Research Area
Cell Adhesion

References & Citations

Ang XM et al. Macromolecular Crowding Amplifies Adipogenesis of Human Bone Marrow- Derived Mesenchymal Stem Cellsby Enhancing the Pro-Adipogenic Microenvironment. Tissue Engineering Part A Volume 20: 966, 2014. Western blottingGorur A. et al. COPII-coated membranes function as transport carriers of intracellular procollagen I. J Cell Biol April 20, 2017, PMID 28428367. Immunofluorescence
Indirect Elisa Protocol
IHC
General Western Blot Protocol

Formats Available

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Prod No.
Description
42025
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.