Anti-Imipramine [Clone IM11-214.1]

Imipramine conjugated to KLH.

This monoclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.2 - 7.4 with no carrier protein or preservatives added.

Liquid

Antibodies are purified by a multi-step process including the use of PEG purification chromatography.

This antibody is stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Next Day 2-8°C

Mouse Monoclonal Antibody specific to Imipramine.

Anti-Imipramine Monoclonal Antibody (Clone IM11-214.1); Understanding the Target: What is Imipramine?

Imipramine is a prominent, first-generation tricyclic antidepressant (TCA) belonging to the dibenzazepine group. Historically one of the first major antidepressants developed, it is primarily prescribed for the treatment of major depressive disorders and childhood enuresis. Imipramine functions by inhibiting the reuptake of neurotransmitters—specifically serotonin and norepinephrine—in the central nervous system, thereby elevating mood and alleviating depressive symptoms.

Due to its narrow therapeutic index and the potential for severe side effects or toxicity at high doses, precise monitoring of imipramine levels in patient samples is highly critical for both patient safety and therapeutic efficacy.

The IgM Advantage in Immunoassay Development

Unlike standard IgG antibodies, Clone IM11-214.1 is a Mouse IgM isotype. In the world of diagnostic assay design, utilizing an IgM antibody can offer a distinct biochemical advantages:

- High Functional Avidity: Due to its characteristic pentameric structure, IgM possesses 10 antigen-binding sites. This multivalent nature provides exceptional binding strength (avidity), making it highly effective at capturing small molecule haptens like imipramine, even at low concentrations.

- Excellent Solid-Phase Coating: IgM antibodies often excel as capture reagents on solid phases, such as ELISA plates or lateral flow membranes, providing a robust layout for competitive immunoassay formats.

- Alternative Cross-Reactivity Profiles: Because IgM clones recognize epitopes differently than IgGs, Clone IM11-214.1 is a crucial inclusion in antibody screening panels to identify unique cross-reactivity profiles against other TCAs or metabolites like desipramine.

Developed by QED Bioscience and supplied by Leinco Technologies, Clone IM11-214.1 is a highly purified mouse monoclonal IgM antibody. It is optimized primarily for Enzyme-Linked Immunosorbent Assays (ELISA) and exhibits strong, reliable binding characteristics when evaluated against imipramine-protein conjugates. To ensure maximum flexibility for assay developers, this antibody is supplied in a purified, carrier-free phosphate-buffered saline (PBS) format without added preservatives or stabilizing proteins. This clean formulation allows for seamless downstream processing, biotinylation, or enzyme conjugation.