Anti-mGluR1/5 Glutamate Receptor Antibody (56526)

Fusion protein corresponding to aa 824-1203 (cytoplasmic C-terminus) of rat mGluR5b (accession no. NP_058708.1).

PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.Purified by Protein G affinity chromatography.

Liquid

Purified by Protein G affinity chromatography

This product is stable for at least 1 year at -20°C. Freeze in multiple aliquots to avoid repeated freeze-thaw cycles.

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.

Next Day 2-8°C

This antibody recognizes human, mouse, and rat mGluR1/5.

The metabotropic glutamate receptors (mGluRs) are glutamate receptors that are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors (GPCRs). The mGluRs perform a variety of functions in the central and peripheral nervous systems. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and the cerebral cortex, as well as other parts of the brain and in peripheral tissues. Unlike ionotropic receptors, metabotropic glutamate receptors are not ion channels. Instead, they activate biochemical cascades, leading to the modification of other proteins.

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium sPubMed:1320017, PubMed:21795692}.