Anti-Mouse CD54 (ICAM-1) (Clone YN1/1.7.4) – Purified
Anti-Mouse CD54 (ICAM-1) (Clone YN1/1.7.4) – Purified
Product No.: C2151
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Clone YN1/1.7.4 Target CD54 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Ly-47 Isotype IgG2b κ Applications FC , IHC FF , IP , PhenoCycler® , WB |
Data
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Product Concentration 0.5 mg/ml Formulation This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This purified antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2829235 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Clone YN1/1.7.4 recognizes an epitope on mouse CD54. Antigen Distribution CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes. Background ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies. Antigen DetailsLigand/Receptor CD11a/CD18 (LFA-1) or CD11b/CD18 (Mac-1) and CD11c/CD18, CD43, hyaluronan, fibrinogen PubMed NCBI Gene Bank ID UniProt.org Research Area Cell Adhesion . Cell Biology . Costimulatory Molecules . Immunology . Innate Immunity . Neuroscience . Neuroscience Cell Markers . Stem Cell References & Citations1. Li, S. et al. (2009) Biochem. Biophys. Res. Commun. 381: 459
2. Wolf, S. et al. (2009) Pharmacol. Rep. 61: 22
3. Ozcan, U. et al. (2009) Arch Gynecol. Obstet. Technical Protocols |
Formats Available
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Prod No. | Description |
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C2401 | |
C2396 | |
C2151 | |
C2392 | |
C2394 | |
C2393 | |
C2397 | |
C2398 | |
C2399 | |
C2400 | |
C2395 | |
C527 | |
C2391 | |
C6391 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.