Anti-Mouse Common Gamma Chain

Product No.: C1477


Target Common Gamma Chain Product Type Polyclonal Antibody Alternate Names Common Cytokine Receptor Gamma Chain, CD132, Interleukin 2 Receptor Gamma Chain (IL-2 Rγ) Applications ELISA Indirect , N , WB


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Data


Antibody Details Product Details Reactive Species Mouse Host Species Goat Immunogen Sf 21-Derived Recombinant Mouse Gamma_c Extracellular Domain Endotoxin Level <0.1 EU/µg as determined by the LAL method Formulation This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present. State of Matter Lyophilized Storage and Handling The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months. Country of Origin USA Shipping Next Day Ambient RRIDAB_2828542 Applications and Recommended Usage? Quality Tested by Leinco Western Blotting: To detect Mouse Common Gamma Chain this polyclonal antibody can be used at a concentration of 0.1 - 0.2 µg/ml. This polyclonal antibody should be used in conjunction with compatible second-step reagents such as PN:G505 and a chromogenic substrate such as PN:T343. The detection limit for Mouse Common Gamma Chain is 2 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. Additional Applications Reported In Literature ? Neutralization: This antibody is useful for neutralization of Mouse Common Gamma Chain bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse Common Gamma Chain (at 0.8 ng/ml) is 6 - 24 µg/ml. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Goat Anti-Mouse Common Gamma Chain recognizes Mouse Common Gamma Chain. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research. Background The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for IL-4, IL-7, IL-9, and IL-15 as well as IL-2.¹ It is a cytokine receptor subunit that is located on the surface of certain sub-sets of lymphocytes (white blood cells). Common gamma-chain is critical for lymphocyte development. PubMed Common Gamma Chain NCBI Gene Bank ID 16186 UniProt.org More Information on Uniprot.org References & Citations 1. Sugamura, K. et al. (2001) J Immunol. 167: 1 View product citations for antibody C1477 on CiteAb Technical Protocols N Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Mouse

Host Species

Goat

Immunogen

Sf 21-Derived Recombinant Mouse Gamma_c Extracellular Domain

Endotoxin Level

<0.1 EU/µg as determined by the LAL method

Formulation

This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.

State of Matter

Lyophilized

Storage and Handling

The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.

Country of Origin

USA

Shipping

Next Day Ambient

RRIDAB_2828542

Applications and Recommended Usage?
Quality Tested by Leinco

Western Blotting: To detect Mouse Common Gamma Chain this polyclonal antibody can be used at a concentration of 0.1 - 0.2 µg/ml. This polyclonal antibody should be used in conjunction with compatible second-step reagents such as PN:G505 and a chromogenic substrate such as PN:T343. The detection limit for Mouse Common Gamma Chain is 2 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used.

Additional Applications Reported In Literature ?

Neutralization: This antibody is useful for neutralization of Mouse Common Gamma Chain bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse Common Gamma Chain (at 0.8 ng/ml) is 6 - 24 µg/ml.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Goat Anti-Mouse Common Gamma Chain recognizes Mouse Common Gamma Chain. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

Background

The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for IL-4, IL-7, IL-9, and IL-15 as well as IL-2.¹ It is a cytokine receptor subunit that is located on the surface of certain sub-sets of lymphocytes (white blood cells). Common gamma-chain is critical for lymphocyte development.

PubMed

Common Gamma Chain

NCBI Gene Bank ID

16186

UniProt.org

More Information on Uniprot.org