Anti-Mouse EphA7 – Biotin

NS0-Derived Recombinant Mouse EphA7 Extracellular Domain (Accession # Q61772)

This biotinylated antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 50 µg of bovine serum albumin per µg of antibody with no calcium, magnesium, or preservatives present.

The lyophilized, biotinylated antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for up to twelve months from date of receipt. The reconstituted biotin conjugate can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted conjugate, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.

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Goat Anti-Mouse EphA7 recognizes Mouse EphA7. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

EPH receptor A7, also known as EPHA7 is a receptor tyrosine kinase of the Eph family.¹ EPHA7 functions as a cell-cell contact-mediated signalling in dorsal limb patterning and/or axon guidance.² EphA7 is expressed early in cortical development, becoming concentrated in anterior and posterior domains.³ EphA7 may have roles in the pathogenesis and development of gastric⁴ and colorectal⁵ carcinomas.

1. Muir, EM. et al. (1999) Brain Res Mol Brain Res. 74: 225
2. Nieto, MA. et al. (1998) Development 125: 4195
3. Donoghue, MJ. et al. (2006) J Comp Neurol. 496: 627
4. Zhou, X. et al. (2007) Hum Pathol. 38: 1649
5. Sugimura, H. et al. (2005) Oncogene 24: 5637