Anti-Mouse/Human CD44 (Clone IM7) – PerCP

Home/Primary Monoclonal Antibodies/Surfacetag Mouse CD Markers/Anti-Mouse/Human CD44 (Clone IM7) – PerCP

Pricing & Details

Product No.C1894
Clone
IM7
Protein
CD44
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Pgp-1, Ly-24, H-CAM
Isotype
Rat
IgG2b
Applications
FC
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1894-Custom
Custom
In stock
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Mouse
Host Species
Rat
Immunogen
Purified Recombinant Mouse CD44 (>98%)
Product Concentration
0.2 mg/ml
Formulation
This PerCP conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This PerCP conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone IM7 recognizes an epitope common to alloantigens and all isoforms of CD44 that is located between amino acids 145 and 186.
Antigen Distribution
CD44 is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells in addition to B-cells, monocytes, macrophages and certain subsets of thymocytes and peripheral T-cells. Mice with the Ly-24.1 allotype have high densities of CD44+ T-cells.
Background
CD44 is an 80-95 kD glycoprotein that plays a role in various cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. CD44 interacts with osteopontin, collagens, and matrix metalloproteinases (MMPs) and is a receptor for hyaluronic acid. Transcripts for this gene go through intricate alternative splicing that result in a variety of functionally distinct isoforms, including those which may be related to tumor metastasis. These splice variants of CD44 function as receptors under hemodynamic flow conditions that are significant to the development of cancer metastasis. Hence, it is thought that anti-CD44 tumor-specific mAbs may have therapeutic potential. This therapeutic potential of anti-CD44 mAbs is evident in some animal experiments demonstrating a reduction in malignant activities of various neoplasms when CD44 was targeted by a combination of mAbs, antisense oligonucleotides, and CD44-soluble proteins. It has been reported that high levels of CD44 on leukemic cells fuel leukemia production. Notably, various cancer studies show conflicting results pertaining to level of CD44 expression and its correlation with disease prognosis. Before anti-CD44 therapy can be applied to human cancers, it is essential to resolve this inconsistency.

Antigen Details

Protein
Ligand/Receptor
Hyaluronan, MIP-1β, fibronectin, collagen
PubMed
NCBI Gene Bank ID
Research Area
Cell Adhesion
.
Cell Biology
.
Immunology
.
Stem Cell

References & Citations

1. Trowbridge, I. et al. (1982) Immunogenetics 15:299 2. Lesley, J. et al. (1988) Cell Immunol. 112:40
Flow Cytometry

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.