Anti-Mouse ICAM-1 (CD54) (Clone BE29G1) – Biotin

Anti-Mouse ICAM-1 (CD54) (Clone BE29G1) – Biotin

Product No.: C268

[product_table name="All Top" skus="C268"]

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Clone
BE29G1
Target
Inter-Cellular Adhesion Molecule 1
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
BB2, CD54, P3.58
Isotype
IgG2a
Applications
FC
,
IHC FF

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Product Size
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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Rat
Immunogen
Purified Recombinant Mouse ICAM-1 (>98%)
Product Concentration
0.5 mg/ml
Formulation
This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rat Anti-Mouse CD54 (Clone BE29G1) recognizes the (Mr 95 kD) cell surface glycoprotein known as intracellular adhesion molecule ICAM-1. ICAM-1 is the receptor for LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18).1,2,3
Antigen Distribution
The CD54 antigen is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes. It has been demonstrated that ICAM-1 enhances T-cell activation.
Background
Intercellular adhesion molecule-1 (ICAM-1) is one of an important cell adhesion molecules (CAMs) family transmembrane glycoprotein1 and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines.2 ICAM-1 is a marker of endothelial dysfunction leading to damaging vascular disorders, in umbilical and placental vascular tissue of gestational pregnancies.3

Antigen Details

Ligand/Receptor
CD11a/CD18 (LFA-1) or CD11b/CD18 (Mac-1) and CD11c/CD18, CD43, hyaluronan, fibrinogen
NCBI Gene Bank ID
Research Area
Cell Adhesion
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Cell Biology
.
Costimulatory Molecules
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Immunology
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Innate Immunity
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Neuroscience
.
Neuroscience Cell Markers
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Stem Cell

References & Citations

1. Li S et al. (2009) Biochem Biophys Res Commun. 381: 459 2. Wolf S et al. (2009) Pharmacol Rep 61: 22 3. Ozcan U et al. (2009) Arch Gynecol Obstet.
Flow Cytometry
IHC FF
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.