Anti-Mouse IgD (Clone 11-26c.2a) – APC
Anti-Mouse IgD (Clone 11-26c.2a) – APC
Product No.: I-1413
- -
- -
Clone 11-26c.2a Target Mouse IgD Formats AvailableView All Product Type Hybridoma Monoclonal Antibody Alternate Names Immunoglobulin D Isotype Rat IgG2a κ Applications FC , IF , IHC , IP |
- -
- -
Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Product Concentration 0.2 mg/ml Formulation This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. State of Matter Liquid Storage and Handling This Allophycocyanin (APC) conjugate is stable when stored at 2-8°C. Do not freeze. Regulatory Status Research Use Only Country of Origin USA Shipping 2 – 8° C Wet Ice Excitation Laser Red Laser (650 nm) Additional Applications Reported In Literature ? FC, IF, IHC, IP Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone 11-26c.2a specifically reacts with the delta heavy chain of mouse IgD, without cross-
reacting with other classes of mouse immunoglobulin like IgA, IgG, or IgM.
Background Immunoglobulin D (IgD) is one of the five main classes of immunoglobulins. Though it is an antibody that is not well understood, it has been discovered to have a vital role in both innate and adaptive immunity. It aids in activating and regulating B cells, especially in the upper respiratory mucosa. In this location, it enhances immune surveillance and defense against respiratory pathogens1. IgD also helps maintain a healthy microbiome by equipping myeloid effector cells with IgD antibodies that react to mucosal antigens, including both commensal and pathogenic microbes2. The 11-26c.2a clone is an essential tool in immunology research, particularly in the study of B cell development and activation pathways. It is widely used in flow cytometric analysis to identify surface IgD expression on mouse B cells. This provides valuable insights into B cell populations and their roles in immune responses3,4. When the antibody is conjugated, it allows for easy detection and multiplexing in flow cytometry, enabling comprehensive immunophenotyping studies5,6. Antigen Distribution IgD is expressed by peripheral mature B cells.
NCBI Gene Bank ID UniProt.org Research Area Immunology References & Citations1. Chen K, Xu W, Wilson M, et al. Nat Immunol. 2009;10(8):889-898. 2. Gutzeit C, Chen K, Cerutti A. Eur J Immunol. 2018;48(7):1101-1113. 3. Böhmer RM, King NJ. Cytometry. 1984;5(5):543-546. 4. Olejniczak SH, Stewart CC, Donohue K, Czuczman MS. Immunol Invest. 2006;35(1):93-114. 5. Pearson T, Galfrè G, Ziegler A, Milstein C. Eur J Immunol. 1977;7(10):684-690. 6. T B, G K, A K, A F, E U, P N. Journal of immunological methods. 1998;214(1-2). 7. Hamilton AM, Lehuen A, Kearney JF. Int Immunol. 1994;6(3):355-361. 8. Ishihara K, Wood WJ, Wall R, et al. J Immunol. 1993;150(6):2253-2262. 9. Nitschke L, Kosco MH, Köhler G, Lamers MC. Proc Natl Acad Sci U S A. 1993;90(5):1887-1891. 10. Campbell KS, Cambier JC. EMBO J. 1990;9(2):441-448. Technical ProtocolsCertificate of Analysis |
Formats Available
- -
- -
Prod No. | Description |
---|---|
I-1411 | |
I-1412 | |
I-1415 | |
I-1410 | |
I-1413 | |
I-1414 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.