Anti-Mouse IL-1β-Purified

Anti-Mouse IL-1β-Purified

Product No.: I-436

[product_table name="All Top" skus="I-436"]

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Clone
B122
Target
Interleukin-1 Beta
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
IL1B, IL-1, IL1-Beta, IL1F2
Isotype
IgG
Applications
IHC FFPE
,
IP
,
WB

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Data

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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Armenian Hamster
Product Concentration
0.5 mg/ml
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Anti-Mouse IL-1β (Clone B122) recognizes Mouse IL-1β. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
Interleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family that is synthesized as a precursor. The IL1 beta precursor form is not biologically active. It is expressed mainly by stimulated macrophages and monocytes.1,2 IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohns disease which makes IL1 beta an important target for this disease.3
Research Area
Immunology
.
Innate Immunity

References & Citations

1. Dinarello CA et al. (1996) Blood 87: 2095 2. Yuan et al. (1993) Cell 75: 641 3. Shin Maeda et al. (2005) Science 4: 735
IHC FFPE
Immunoprecipitation Protocol
General Western Blot Protocol

Certificate of Analysis

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.