Anti-Mouse IL-1β-Purified

Pricing & Details

Product No.I-436
Clone
B122
Protein
Interleukin-1 Beta
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
IL1B, IL-1, IL1-Beta, IL1F2
Isotype
Armenian Hamster
IgG
Applications
IHC FFPE
,
IP
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-436-50 µg
50 µg
$88.00
In stock
Max:
Min: 1
Step: 1
I-436-500 µg
500 µg
$225.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Mouse
Host Species
Armenian Hamster
Product Concentration
0.5 mg/ml
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Anti-Mouse IL-1β (Clone B122) recognizes Mouse IL-1β. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
Interleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family that is synthesized as a precursor. The IL1 beta precursor form is not biologically active. It is expressed mainly by stimulated macrophages and monocytes.1,2 IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohns disease which makes IL1 beta an important target for this disease.3

Antigen Details

Research Area
Immunology
.
Innate Immunity

References & Citations

1. Dinarello CA et al. (1996) Blood 87: 2095 2. Yuan et al. (1993) Cell 75: 641 3. Shin Maeda et al. (2005) Science 4: 735
IHC
Immunoprecipitation Protocol
General Western Blot Protocol

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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