Anti-Mouse Osteoprotegerin

NS0 - Derived Mouse OPG

This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.

Lyophilized

The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.

Next Day Ambient

Neutralization: This antibody is useful for neutralization of Mouse OPG bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse OPG (at 0.1 ng/ml) is 0.5-2.0 µg/ml.
Immunohistochemistry: Suitable for use at concentration of 5-15 µg/mL.

Goat Anti-Mouse Osteoprotegerin (OPG) recognizes Mouse OPG. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor (OCIF) is a cytokine, which can inhibit osteoclast differentiation, activity, and survival.¹ It is a member of the tumor necrosis factor (TNF) receptor superfamily.² OPG may provide a pharmacological tool for osteoporotic and erosive bone disorders.³

1. Kurihara, H. et al. (2002) Cytokine 18: 133
2. Schoppet, M. et al. (1980) Arteriosclerosis, Thrombosis, & Vascular Biol. 22: 549
3. Dunstan, CR. et al. (2001) J Bone Miner Res. 16: 348