Anti-Mouse Osteoprotegerin (Clone 110517)

Product No.: O127


Clone 110517 Target Osteoprotegerin Formats AvailableView All Product Type Monoclonal Antibody Alternate Names TNFRSF11B, Osteoclast Inhibitory Factor (OCIF), MGC29565, TR1, OCIT Isotype IgG2a Applications WB


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Antibody Details Product Details Reactive Species Mouse Host Species Rat Immunogen NS0-Derived Recombinant Mouse OPG Endotoxin Level <0.1 EU/µg as determined by the LAL method Formulation This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. Storage and Handling The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months. Country of Origin USA Shipping Next Day Ambient RRIDAB_2831494 Applications and Recommended Usage? Quality Tested by Leinco Western Blotting: To detect Mouse OPG this monoclonal antibody can be used at a concentration of 1-2 µg/ml. This monoclonal antibody should be used in conjunction with compatible second-step reagents such as PN:R377 and a chromogenic substrate such as PN:T343. The detection limit for Mouse OPG is 20 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Rat Anti-Mouse Osteoprotegerin (OPG) (Clone 110517) recognizes an epitope on Mouse OPG. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Background Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor (OCIF) is a cytokine, which can inhibit osteoclast differentiation, activity, and survival.¹ It is a member of the tumor necrosis factor (TNF) receptor superfamily.² OPG may provide a pharmacological tool for osteoporotic and erosive bone disorders.³ PubMed Osteoprotegerin References & Citations 1. Kurihara, H. et al. (2002) Cytokine 18: 133 2. Schoppet, M. et al. (1980) Arteriosclerosis, Thrombosis, & Vascular Biol. 22: 549 3. Dunstan, CR. et al. (2001) J Bone Miner Res. 16: 348 View product citations for antibody PRODUCT_CODE on CiteAb Technical Protocols Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Mouse

Host Species

Rat

Immunogen

NS0-Derived Recombinant Mouse OPG

Endotoxin Level

<0.1 EU/µg as determined by the LAL method

Formulation

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Storage and Handling

The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

Country of Origin

USA

Shipping

Next Day Ambient

RRIDAB_2831494

Applications and Recommended Usage?
Quality Tested by Leinco

Western Blotting: To detect Mouse OPG this monoclonal antibody can be used at a concentration of 1-2 µg/ml. This monoclonal antibody should be used in conjunction with compatible second-step reagents such as PN:R377 and a chromogenic substrate such as PN:T343. The detection limit for Mouse OPG is 20 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Rat Anti-Mouse Osteoprotegerin (OPG) (Clone 110517) recognizes an epitope on Mouse OPG. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background

Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor (OCIF) is a cytokine, which can inhibit osteoclast differentiation, activity, and survival.¹ It is a member of the tumor necrosis factor (TNF) receptor superfamily.² OPG may provide a pharmacological tool for osteoporotic and erosive bone disorders.³

PubMed

Osteoprotegerin

References & Citations

1. Kurihara, H. et al. (2002) Cytokine 18: 133
2. Schoppet, M. et al. (1980) Arteriosclerosis, Thrombosis, & Vascular Biol. 22: 549
3. Dunstan, CR. et al. (2001) J Bone Miner Res. 16: 348

View product citations for antibody PRODUCT_CODE on CiteAb

Certificate of Analysis

Request COA

Prod No.	Description
O129	Anti-Human Osteoprotegerin (Clone 69146)
O127	Anti-Mouse Osteoprotegerin (Clone 110517)
O125	Anti-Mouse Osteoprotegerin
O122	Recombinant Mouse Osteoprotegerin
O102	Recombinant Human Osteoprotegerin (OPG)
O137	Recombinant Human Osteoprotegerin
O132	Anti-Mouse Osteoprotegerin – Biotin
O105	Anti-Human Osteoprotegerin – Biotin

Formats Available

Prod No.	Description
O127	Anti-Mouse Osteoprotegerin (Clone 110517)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

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Anti-Mouse Osteoprotegerin (Clone 110517)