Anti-Pregnancy Associated Plasma Protein A (PAPPA)

Anti- Pregnancy Associated Plasma Protein A (PAPP-A) (Clone PAPP-6611)

Product No.: P517


Clone PAPP-6611 Target PAPP-A Formats AvailableView All Product Type Hybridoma Monoclonal Antibody Alternate Names Pregnancy Associated Plasma Protein A, PAPP-A, PAPPA, Pappalysin 1 Isotype Mouse IgG2a Applications ELISA , IP


Select Product Size 250 µg — $270.00	Qty Max: Min: 1 Step: 1 $270.00 ADD TO CART Login For mAb Advantage Pricing Contact Us for Bulk Quantities


Antibody Details Product Details Reactivity Species Human Host Species Mouse Product Concentration ≥1.0 mg/ml Purity ≥90% Formulation Formulated in 0.01 M phosphate buffered saline, pH 7.2 and contains 0.1% sodium azide. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration. State of Matter Liquid Product Preparation This monoclonal antibody is purified by protein A chromatography or sequential differential precipitations. Storage and Handling This purified antibody is stable when stored at 2-8°C. Do not freeze. Regulatory Status Research Use Only Country of Origin USA Shipping 2-8°C Wet Ice Applications and Recommended Usage? Quality Tested by Leinco ELISA, Immunoassays, IP Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Specificity Anti-Human PAPP-A (Clone PAPP-6661) is specific for human Pregnancy Associated Plasma Protein A (PAPP-A). Matched Pair Best ELISA pair (capture/conjugate), PAPP-6611/PAPP-2380. Background Pregnancy-associated plasma protein-A (PAPPA) is a secreted metalloproteinase that cleaves insulin-like growth factor binding proteins to increase the bioavailability of insulin-like growth factors¹. Currently, in conjunction with other biomarkers, it is used in prenatal screening for chromosomal abnormalities including Down syndrome². PAPPA has emerged as a valuable marker in cardiovascular medicine, where elevated levels are associated with an increased risk of adverse cardiovascular events³. It has also been shown to be useful in the detection of gestational diabetes¹ and thyroid cancer ⁴. Antigen Details Research Area Hormones . Matched Pair . IVD Raw Material References & Citations 1. Rojas-Rodriguez, R., et. al. Sci Transl Med. 2020. 12(517):eaay4145. 2. Shiefa S, et. al. Indian J Clin Biochem. 2013. 28(1):3-12. 3. Mythili S, Malathi N. Biomed Rep. 2015. 3(6):743-748. 4. Marzocchi C, et. al. Int J Mol Sci. 2022. 23(9):4648. Technical Protocols

Antibody Details

Product Details

Reactivity Species

Human

Host Species

Mouse

Product Concentration

≥1.0 mg/ml

Purity

≥90%

Formulation

Formulated in 0.01 M phosphate buffered saline, pH 7.2 and contains 0.1% sodium azide. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.

State of Matter

Liquid

Product Preparation

This monoclonal antibody is purified by protein A chromatography or sequential differential precipitations.

Storage and Handling

This purified antibody is stable when stored at 2-8°C. Do not freeze.

Regulatory Status

Research Use Only

Country of Origin

USA

Shipping

2-8°C Wet Ice

Applications and Recommended Usage?
Quality Tested by Leinco

ELISA,
Immunoassays,
IP

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Anti-Human PAPP-A (Clone PAPP-6661) is specific for human Pregnancy Associated Plasma Protein A (PAPP-A).

Matched Pair

Best ELISA pair (capture/conjugate), PAPP-6611/PAPP-2380.

Background

Pregnancy-associated plasma protein-A (PAPPA) is a secreted metalloproteinase that cleaves insulin-like growth factor binding proteins to increase the bioavailability of insulin-like growth factors¹. Currently, in conjunction with other biomarkers, it is used in prenatal screening for chromosomal abnormalities including Down syndrome².

PAPPA has emerged as a valuable marker in cardiovascular medicine, where elevated levels are associated with an increased risk of adverse cardiovascular events³. It has also been shown to be useful in the detection of gestational diabetes¹ and thyroid cancer ⁴.

Antigen Details

Research Area

Hormones

Matched Pair

IVD Raw Material

References & Citations

1. Rojas-Rodriguez, R., et. al. Sci Transl Med. 2020. 12(517):eaay4145.
2. Shiefa S, et. al. Indian J Clin Biochem. 2013. 28(1):3-12.
3. Mythili S, Malathi N. Biomed Rep. 2015. 3(6):743-748.
4. Marzocchi C, et. al. Int J Mol Sci. 2022. 23(9):4648.

Formats Available

Prod No.	Description
P517	Anti- Pregnancy Associated Plasma Protein A (PAPP-A) (Clone PAPP-6611)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

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Anti- Pregnancy Associated Plasma Protein A (PAPP-A) (Clone PAPP-6611)