Anti- Pregnancy Associated Plasma Protein A (PAPP-A) (Clone PAPP-6611)
Anti- Pregnancy Associated Plasma Protein A (PAPP-A) (Clone PAPP-6611)
Product No.: P517
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Clone PAPP-6611 Target PAPP-A Formats AvailableView All Product Type Hybridoma Monoclonal Antibody Alternate Names Pregnancy Associated Plasma Protein A, PAPP-A, PAPPA, Pappalysin 1 Isotype Mouse IgG2a Applications ELISA , IP |
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Antibody DetailsProduct DetailsReactivity Species Human Host Species Mouse Product Concentration ≥1.0 mg/ml Purity ≥90% Formulation Formulated in 0.01 M phosphate buffered saline, pH 7.2 and contains 0.1% sodium azide. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration. State of Matter Liquid Product Preparation This monoclonal antibody is purified by protein A chromatography or sequential differential precipitations. Storage and Handling This purified antibody is stable when stored at 2-8°C. Do not freeze. Regulatory Status Research Use Only Country of Origin USA Shipping 2-8°C Wet Ice Applications and Recommended Usage? Quality Tested by Leinco ELISA, Immunoassays, IP Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Anti-Human PAPP-A (Clone PAPP-6661) is specific for human Pregnancy Associated Plasma Protein A (PAPP-A). Matched Pair Best ELISA pair (capture/conjugate), PAPP-6611/PAPP-2380. Background Pregnancy-associated plasma protein-A (PAPPA) is a secreted metalloproteinase that cleaves insulin-like growth factor binding proteins to increase the bioavailability of insulin-like growth factors1. Currently, in conjunction with other biomarkers, it is used in prenatal screening for chromosomal abnormalities including Down syndrome2.
PAPPA has emerged as a valuable marker in cardiovascular medicine, where elevated levels are associated with an increased risk of adverse cardiovascular events3. It has also been shown to be useful in the detection of gestational diabetes1 and thyroid cancer 4. Antigen DetailsResearch Area Hormones . Matched Pair References & Citations1. Rojas-Rodriguez, R., et. al. Sci Transl Med. 2020. 12(517):eaay4145.
2. Shiefa S, et. al. Indian J Clin Biochem. 2013. 28(1):3-12. 3. Mythili S, Malathi N. Biomed Rep. 2015. 3(6):743-748. 4. Marzocchi C, et. al. Int J Mol Sci. 2022. 23(9):4648. Technical Protocols  |
Formats Available
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Prod No. | Description |
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P517 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
