Anti-S100α/β Antibody (56204)
Anti-S100α/β Antibody (56204)
Product No.: 56204
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Clone 6G1 Target S100α/β Formats AvailableView All Product Type Monoclonal Alternate Names S-100 proteinα chain, S-100 protein subunitα, S100 calcium-binding protein A1 Isotype Mouse IgG1 Applications ELISA , WB , AP |
Data
20% PAGE w/ 2mM EGTA, 1 ug Antigen. - -
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Purified S-100 protein from human brain. Product Concentration Lot Specific Formulation PBS, pH 7.4, 0.09% sodium azide State of Matter Liquid Product Preparation Purified by Protein A affinity chromatography Storage and Handling These antibodies are stable for at least one (1) year at -20°C to -70°C. Avoid multiple freeze-thaw cycles. Regulatory Status Research Use Only Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco These antibodies may be used in ELISA and Western blot (human brain): 56203, 56204, and 56206 may be used to affinity-purify S-100.Recommended pairs for sandwich ELISA: Capture Detect 56203 56204 56206 56204 Additional Applications Reported In Literature ? AP, ELISA, WB Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity 56203, 56204, and 56205 recognize S-100αβ and S-100 ββ. Function Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446). {PubMed:11717446, PubMed:12804600, PubMed:22399290, PubMed:23351007}. NCBI Gene Bank ID UniProt.org Research Area Neuroscience References & CitationsTechnical Protocols  AP Certificate of Analysis |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
