Anti-Treponema pallidum, Tp47 (TPAL-6274)

Anti-Treponema pallidum, Tp47 (TPAL-6274)

Product No.: T818

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Clone
TPAL-6274
Target
Tp47
Formats AvailableView All
Product Type
Hybridoma Monoclonal Antibody
Alternate Names
Syphilis
Isotype
Mouse IgG2b
Applications
ELISA
,
IF
,
WB

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Select Product Size
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Antibody Details

Product Details

Reactivity Species
Treponema pallidum
Host Species
Mouse
Product Concentration
≥1.0 mg/ml
Purity
≥90%
Formulation
Formulated in 0.01 M phosphate buffered saline, pH 7.2 and contains 0.1% sodium azide. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
State of Matter
Liquid
Product Preparation
This monoclonal antibody is purified by protein A chromatography or sequential differential precipitations.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Regulatory Status
Research Use Only
Country of Origin
USA
Shipping
2-8°C Wet Ice
Applications and Recommended Usage?
Quality Tested by Leinco
ELISA: 1:20-1:200,
IF: 1:10-1:50,
WB
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Anti-Treponema pallidum (Clone TPAL-6274) is specific for the immunodominant Tp47 protein of T. pallidum. This antibody does not cross react with Borrelia burgdorferi.
Background
Treponema pallidum is a Gram-negative spirochete that is the causative agent of the STI syphilis. Untreated syphilis typically has four stages, each marked with different symptoms. During late stages of infection, syphilis can lead to serious complications involving the nervous system, cardiovascular system, and other organs such as the eyes and ears. Syphilis can be passed from mother to child during both pregnancy and childbirth, leading to serious effects including miscarriages & stillbirths. Disease can also cause potential birth defects such as deformed bones, anemia, meningitis and deafness or blindness. Tp47 (p47) is a 47-kDa lipoprotein of T. pallidum that is strongly immunogenic. It has been shown to be an abundant penicillin-binding protein (PBP) in T. pallidum that is used in serological diagnostic screening.

Antigen Details

Antigen
Tp47
Research Area
Bacteria
.
Infectious Disease
.
Sexually Transmitted Infections
Indirect Elisa Protocol
IF
General Western Blot Protocol

Formats Available

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Products are for research use only. Not for use in diagnostic or therapeutic procedures.