Recombinant Human IL-13

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Pricing & Details

Product. No.I-195
Alternate Names
Interleukin-13, ALRH, BHR1, MGC116786, P600, NC30, MGC116788, MGC116789
Expression Host
E. coli
Prod No.
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I-195-5 µg
5 µg
In stock
Min: 1
Step: 1
I-195-25 µg
25 µg
In stock
Min: 1
Step: 1
I-195-100 µg
100 µg
In stock
Min: 1
Step: 1


Interleukin 13 (IL-13), also known as ALRH, is a single-chain, glycosylated polypeptide and a cytokine that is critical in regulating inflammatory and immune responses.1 It is produced primarily by activated Th2 cells, as well as mast cells and Natural Killer (NK) cells.1 The functions of IL-13 overlap considerably with those of IL-4 but these effects are probably less important given the more potent role of IL-4.2 IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα), and at least one of two known IL-13-specific binding chains (IL13 Rα1 and IL13 Rα2). Most of the biological effects of IL-13, like those of IL-4, are linked to signal transducer and activator of transcription 6 (STAT6).2 Although IL-13 is associated primarily with the induction of airway disease, it also has anti-inflammatory properties. It exerts these anti-inflammatory effects on monocytes and macrophages, and inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE.3 Blocking of IL-13 activity inhibits the pathophysiology of asthma.4 Targeted deletion of IL-13 in mice results in impaired Th2 cell development and indicates an important role for IL-13 in the expulsion of gastrointestinal parasites.5 In addition, studies have identified IL-13 expression as a common feature of cHL (classical Hodgkin lymphoma).6 Human and murine IL-13 are cross-species reactive.

Protein Details

>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human IL-13 was determined in a cell proliferation assay using a human factor-dependent cell line, TF-1 (Kitamura, T. et al., 1989, J. Cell Physiol. 140:323). The expected ED50 for this effect is typically 0.75 - 3.5 ng/ml. The cell number is assessed in a fluorometric assay using the redox sensitive dye, Resazurin.
Expression Host
E. coli
Amino Acid Sequence
gpvppstalr elieelvnit qnqkaplcng smvwsinlta gmycaalesl invsgcsaie ktqrmlsgfc phkvsagqfs slhvrdtkie vaqfvkdlll hlkklfregr fn
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-13 is Mr 12.3 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 9 kDa. The 110 residue protein is C-terminally truncated.
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Wynn, TA. et al. (2003) Annu Rev Immunol. 21: 425
2. Citrin, DE. et al. (2016) Sci Rep. 6:39714.
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.