Recombinant Mouse IL-13

Home/Recombinant Proteins/Recombinant Mouse IL-13

Pricing & Details

Product. No.I-278
Alternate Names
Interleukin-13, ALRH, BHR1, MGC116786, P600, NC30
Expression Host
E. coli
Species
Mouse
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-278-5 µg
5 µg
$309.00
In stock
Max:
Min: 1
Step: 1
I-278-25 µg
25 µg
$969.00
In stock
Max:
Min: 1
Step: 1
I-278-50 μg
50 µg
$989.00
In stock
Max:
Min: 1
Step: 1

Background

Interleukin 13 (IL-13) is a cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells1, that is an important mediator of allergic inflammation and disease. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα), which is also a component of the IL-4 receptor, and at least one of two known IL-13-specific binding chains.1 The functions of IL-13 overlap considerably with those of IL-4. Although IL-13 is associated primarily with the induction of airway disease, it also has anti-inflammatory properties. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01 EU/µg as determined by the LAL method
Biological Activity
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells.3 The ED50 for this effect is 0.75‑3 ng/mL.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
svslpltlke lieelsnitq dqtplcngsm vwsvdlaagg fcvaldsltn isncnaiyrt qrilhglcnr kapttvsslp dtkievahfi tkllsytkql frhgpf
N-terminal Sequence Analysis
Ser26
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse IL-13 is Mr 11.5 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 9 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Wynn, TA. et al. (2003) Annu Rev Immunol. 21: 425
2. Citrin, DE. et al. (2016) Sci Rep. 6:39714.
3. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323.
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.