Recombinant Human Leptin

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Pricing & Details

Product. No.L116
Alternate Names
Obesity Protein (OB), B219, LEP, OBS
Expression Host
E. coli
Prod No.
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L116-1 mg
1 mg
In stock
Min: 1
Step: 1
L116-5 mg
5 mg
In stock
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.



Leptin is a neuroendocrine hormone secreted from adipose tissue that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin is one of the most important adipose derived hormones.1 It interacts with six types of receptors and once it binds to OB-Receptor it activates the stat3, which is phosphorylated and travels to the nucleus to effect changes in gene expression. One of the main effects on gene expression is the down-regulation of the expression of endocannabinoids.2 High leptin levels are associated with psoriasis.3

Protein Details

>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human Leptin was determined by its ability to induce proliferation of leptin-dependent human OB-R transfected murine BaF3 cells. The expected ED50 for this effect is 0.4 - 2 ng/ml.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
mvpiqkvqdd tktliktivt rindishtqs vsskqkvtgl dfipglhpil tlskmdqtla vyqqiltsmp srnviqisnd lenlrdllhv lafskschlp wasgletlds lggvleasgy stevvalsrl qgslqdmlwq ldlspgc
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human Leptin is Mr 16 kDa.
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Mantzoros, CS. et al.(2006) Nat Clin Pract Endocrinol Metab. 2: 318
2. Hill, RA. et al.(2002) Int. J. Obes. Relat. Metab. Disord. 26: 1407
3. Chen, YJ. et al.(2008) Arch Derm. 144: 1571
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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