Recombinant Human SIGIRR

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, also known as SIGIRR is a member of the IL-1 receptor family.¹ It acts as a negative regulator of interleukin (IL)-1 and lipopolysaccharide (LPS) signaling.² It also plays a critical role in gut homeostasis, intestinal inflammation, and colitis-associated tumorigenesis by maintaining the microbial tolerance of the colonic epithelium.³

Fc Fusion Protein

mpgvcdrapd flspsedqvl rpalgssval nctawvvsgp hcslpsvqwl kdglplgigg hyslheyswv kanlsevlvs svlgvnvtst evygaftcsi qnisfssftl qragptshks cdkthtcppc papellggps vflfppkpkd tlmisrtpev tcvvvdvshe dpevkfnwyv dgvevhnakt kpreeqynst yrvvsvltvl hqdwlngkey kckvsnkalp apiektiska kgqprepqvy tlppsrdelt knqvsltclv kgfypsdiav ewesngqpen nykttppvld sdgsfflysk ltvdksrwqq gnvfscsvmh ealhnhytqk slslspgk

Met1

Lyophilized

The predicted molecular weight of Recombinant Human SIGIRR is Mr 39 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 55-60 kDa.

39

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Mantovani, A.et al. (2003) Eur Cytokine Netw. 14: 211
2. Li, X. et al. (2005) J Biol chem. 280: 25233
3. Li, X et al. (2007) Immunity 26: 461