Antibody DetailsProduct DetailsReactivity Species Mouse Product Concentration 0.2 mg/ml Amino Acid Location 15 amino acids near the carboxy-terminus of mouse SIGIRR (1). Formulation This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. Storage and Handling Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Background Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, also known as SIGIRR is a member of the IL-1 receptor family.1 It acts as a negative regulator of interleukin (IL)-1 and lipopolysaccharide (LPS) signaling.2 It also plays a critical role in gut homeostasis, intestinal inflammation, and colitis-associated tumorigenesis by maintaining the microbial tolerance of the colonic epithelium.3 Antigen DetailsProtein PubMed References & Citations1. Mantovani A.et al. (2003) Eur Cytokine Netw. 14: 211
2. Li xet al. (2005) J Biol chem. 280: 25233
3. Li X et al. (2007) Immunity 26: 461
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