Anti-Mouse SIGIRR (CT)
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rabbit Immunogen PN:S559 Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2831784 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Anti-Mouse Single Immunoglobulin Domain-Containing IL-1 Receptor-Related Protein (SIGIRR) recognizes Mouse SIGIRR. This polyclonal antibody was purified using affinity chromatography. Background Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, also known as SIGIRR is a member of the IL-1 receptor family.1 It acts as a negative regulator of interleukin (IL)-1 and lipopolysaccharide (LPS) signaling.2 It also plays a critical role in gut homeostasis, intestinal inflammation, and colitis-associated tumorigenesis by maintaining the microbial tolerance of the colonic epithelium.3 Antigen DetailsPubMed References & Citations1. Mantovani, A. et al. (2003) Eur Cytokine Netw. 14: 211 2. Li, X. et al. (2005) J Biol chem. 280: 25233 3. Li, X. et al. (2007) Immunity 26: 461 Technical Protocols |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
