Recombinant Mouse SIGIRR

Recombinant Mouse SIGIRR

Product No.: S576

[product_table name="All Top" skus="S576"]

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Alternate Names
Single Ig IL-1R-related Molecule, MGC110992, TIR8
Product Type
Recombinant Protein
Expression Host
NS0 Cells
Species
Mouse

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Product Size
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Background

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, also known as SIGIRR is a member of the IL-1 receptor family.1 It acts as a negative regulator of interleukin (IL)-1 and lipopolysaccharide (LPS) signaling.2 It also plays a critical role in gut homeostasis, intestinal inflammation, and colitis-associated tumorigenesis by maintaining the microbial tolerance of the colonic epithelium.3

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01 EU/µg as determined by the LAL method
Fusion Protein Tag
Fc Fusion Protein
Protein Accession No.
Amino Acid Sequence
magvcdmapn flspsedqal glalgreval nctawvfsrp qcpqpsvqwl kdglalgngs hfslhedfwv sanfseivss vlvlnltnae dygtftcsvw nvsshsftlw ragpaghksc dkthtcppcp apellggpsv flfppkpkdt lmisrtpevt cvvvdvshed pevkfnwyvd gvevhnaktk preeqynsty rvvsvltvlh qdwlngkeyk ckvsnkalpa piektiskak gqprepqvyt lppsrdeltk nqvsltclvk gfypsdiave wesngqpenn ykttppvlds dgsfflyskl tvdksrwqqg nvfscsvmhe alhnhytqks lslspgk
N-terminal Sequence Analysis
Met1
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse SIGIRR is Mr 39 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 63 kDa.
Predicted Molecular Mass
39
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Mantovani, A.et al. (2003) Eur Cytokine Netw. 14: 211
2. Li, X.et al. (2005) J Biol chem. 280: 25233
3. Li, X. et al. (2007) Immunity 26: 461
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.