Recombinant Human SMAC

Second Mitochondria Derived Activator of Caspase (SMAC) is a mitochondrial apoptogenic protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs.¹ SMAC promotes cytochrome-c dependent activation by eliminating the inhibition of IAP - a protein that negatively regulates apoptosis or programmed cell death.²

Histidine Tag

Ala56

Lyophilized

The predicted molecular weight of Recombinant Human SMAC is Mr 22 kDa.

22

This recombinant protein was 0.2 µm filtered and is supplied in a solution of 20 mM Hepes and 0.1 M potassium chloride (KCl), pH 7.5.

This protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one week or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day 2-8°C

1. Melendez-Zajgla, J. et al. (2008) J Exp Clin Cancer Res. 26: 27
2. Vucic, D. et al. (2002) J Biol chem. 277: 12275