This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human Second Mitochondria Derived Activator of Caspase (SMAC) recognizes Human SMAC. This polyclonal antibody was purified using affinity chromatography.
Second Mitochondria Derived Activator of Caspase (SMAC) is a mitochondrial apoptogenic protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs.1 SMAC promotes cytochrome-c dependent activation by eliminating the inhibition of IAP - a protein that negatively regulates apoptosis or programmed cell death.2
References & Citations
1. Melendez-Zajgla, J. et al. (2008) J Exp Clin Cancer Res. 26: 27
2. Vucic, D. et al. (2002) J Biol chem. 277: 12275
Products are for research use only. Not for use in diagnostic or therapeutic procedures.