Recombinant Human TWEAK

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Pricing & Details

Product. No.T169
Alternate Names
TNF-Related Weak Inducer of Apoptosis, TNFSF12, DR3LG, Apo3-Ligand
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
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T169-25 µg
25 µg
$359.00
In stock
Max:
Min: 1
Step: 1

Data

Background

TNF-related weak inducer of apoptosis (TWEAK) is a member of the TNF superfamily. This cytokine has overlapping signaling functions with TNF but displays a much wider tissue distribution. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. (1). It has pleiotropic biological functions including proapoptotic, proangiogenic and proinflammatory activities (2-3). TWEAK also induces skeletal muscle atrophy (4). It can function as both as a type II transmembrane protein and as a cleaved soluble protein. TWEAK is the ligand for the FN14/TWEAKR receptor.

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human TNF-Related Weak Inducer of Apoptosis is determined by the dose-dependent stimulation of IL-8 production by Human PBMC. The expected ED50 for this effect is less than 10.0 ng/ml.
Fusion Protein Tag
Histidine Tag
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
hhhhhhhrsa pkgrktrarr aiaahyevhp rpgqdgaqag vdgtvsgwee arinsssplr ynrqigefiv traglyylyc qvhfdegkav ylkldllvdg vlalrcleef sataasslgp qlrlcqvsgl lalrpgsslr irtlpwahlk aapfltyfgl fqv
N-terminal Sequence Analysis
Met
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human TWEAK is 18.3 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) with BSA as a carrier protein. pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Aaron, JW. et al. (2006) Molecular Endo. 20:2528
2. Burkly, LC. et al. (2005) Oncogene 24:2613
3. Young, S. et al. (2003) Biochem. Biophys. Res. Commun. 305:789
4. Kumar, A. et al. (2007) FASEB J. 21:1857
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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