Recombinant Mouse TWEAK

Recombinant Mouse TWEAK

Product No.: T524

[product_table name="All Top" skus="T524"]

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Alternate Names
TNF-Related Weak Inducer of Apoptosis, TNFSF12, DR3L, APO3L, DR3LG
Product Type
Recombinant Protein
Expression Host
E. coli Cells

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Select Product Size
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TNF-related weak inducer of apoptosis (TWEAK), also known as TNFSF12, is a member of the TNF superfamily. This cytokine has overlapping signaling functions with TNF but displays a much wider tissue distribution. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. (1). It has pleiotropic biological functions including proapoptotic, proangiogenic and proinflammatory activities (2-3). TWEAK also induces skeletal muscle atrophy (4). It can function as both as a type II transmembrane protein and as a cleaved soluble protein. TWEAK is the ligand for the FN14/TWEAKR receptor.

Protein Details

>90% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Mouse TWEAK was determined by a cell proliferation assay using HUVEC hUmbilical vein endothelial cells. The expected ED<sub>50</sub>=0.03-0.3 ug/ml.
Fusion Protein Tag
Histidine Tag
Protein Accession No.
Amino Acid Sequence
mraiaah yevhprpgqd gaqagvdgtv sgweetkins ssplrydrqi geftviragl yylycqvhfd egkavylkld llvngvlalr cleefsataa sspgpqlrlc qvsgllplrp gsslrirtlp wahlkaapfl tyfglfqvhh hhhhh
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse TWEAK is Mr 17 kDa.
Predicted Molecular Mass
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Aaron, JW. et al. (2006) Molecular Endo. 20:2528
2. Burkly, LC. et al. (2005) Oncogene 24:2613
3. Young, S. et al. (2003) Biochem. Biophys. Res. Commun. 305:789
4. Kumar, A. et al. (2007) FASEB J. 21:1857
Elisa Sandwich Protocol
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.